Tablet formulation

ABSTRACT

The disclosure is directed to formulations for tablets which are to be deeply grooved to facilitate breaking into predetermined portions by the user. A critical tablet weight for deeply grooved tablets is disclosed.

This application is a division of application Ser. No. 312,469 filed Dec. 6, 1972, now U.S. Pat. No. 3,883,647 dated May 13, 1975.

This invention relates to novel formulations for tablets which are to be deeply grooved. Deeply grooved tablets are those in which the groove is 1/3 to 2/3 of the total tablet thickness. Such tablets are shown for instance in U.S. Pat. No. 224,591 and in copending application Ser. No. 388,142 filed Aug. 6, 1973. The tablet design allows for easy, simple and accurate division of a pharmaceutical tablet.

In the manufacture of tablets a groove, or bisect, or score, may be formed on one of the tablet faces. The groove facilitates breaking of the tablet into two parts by applying pressure while the tablet is held between two fingers or in both hands.

In the pharmaceutical industry dividing a tablet into two or more accurate predetermined parts permits the administration of two or more doses of the active ingredient, or drug, contained in the tablet. Potent drugs are frequently incorporated in small amounts into a total tablet formulation, and the capability to divide the tablet accurately allows for a saving by not having to formulate, package and distribute different sized tablets for a portion of the dose and for the full dose. In addition, it is often beneficial to the chemical stability of the drug to incorporate the full dose in the smallest tablet size available. The inclusion of one-half of that dose in a tablet of similar size decreases the relation of drug to excipients twofold, thus in many cases also increasing the possibility of drug degradation due to drug-excipient interaction.

Some of the problems that arise in the production of regularly grooved tablets are:

1. Depending on its hardness, it is sometimes impossible to break the tablet although it is scored.

2. Scores do not always assure precise division of the tablet.

3. Pharmaceutical tablets of smaller sizes do not allow for ease of holding and breaking; in which case the patient very often resorts to using other means of dividing the tablet which results in losing parts of it or obtaining uneven parts or both.

Typical deeply scored tablets to which the present invention is applicable are shown in the drawings in which:

FIG. 1 is an isometric view of a pharmaceutical tablet employing a deeply scored design:

FIG. 2 is a top plan view thereof:

FIG. 3 is a side elevational view thereof as seen at right angles to FIG. 2;

FIG. 4 is an end elevational view thereof as seen at right angles to FIG. 2;

FIG. 5 is an end elevational view of a pharmaceutical tablet embodying a modification to the form illustrated in FIG. 4; and

FIG. 6 is a bottom view of the embodiments of FIGS. 1 and 5.

The deeply grooved tablet design presents tablet compression characteristics which are not typical of the manufacturing of conventional pharmaceutical tablets. While tablets are usually compacted between uniform surfaces, flat or concave, the deeply grooved tablet design presents a non-uniform compressing surface on one tablet face and a uniform face, spherical or flat, on the other. Such a multiplanar surface presents a process of physical compaction which does not produce the results expected from a conventional compressed tablet. In the process of compaction, the multiplanar surface applies forces, the resultant of which is not vertical. This results in nonuniform stress distribution within the tablet as an independent unit which in turn causes tablet capping and the inadequate imprinting or embossing of indicia of any of its surfaces. In addition, the uneven distribution of stresses results in varying levels of lubrication effectiveness of the tablet planes in contact with the press tooling which, in turn, causes "picking" of material off the tablet surface. To overcome this phenomenon requires a highly cohesive mixture which is at the same time sufficiently lubricated to enable friction-free tooling to tablet contact on all tablet planes. In practice the tablet formulator has to balance the lubricant level against the binder level because the increase of the former will diminish the effect of the latter until the critical region of such action is surpassed.

"Picking" and "sticking" are words of art, meaning part of the tablet sticks to the tips of the upper or lower punch. "Capping" describes a condition in which the tablet laminates into one or more layers.

This invention has been directed principally to the application of specific pharmaceutical formulations incorporating isosorbide dinitrate as the active ingredient, but is applicable to other deeply grooved tablets as well. Isosorbide dinitrate is a potent coronary vasodilator.

It was originally presumed that existing, acceptable, direct compression, tableting compositions could be adequately compressed with deep scoring tooling. Two such compositions were evaluated and surprisingly, it was found that acceptable tablets could not be made. Using a placebo composition (one without an active ingredient) similar to a presently used acceptable isosorbide dinitrate tablet composition, it was determined that, unexpectedly, a total tablet weight was critical to obtain acceptable tablets. To minimize the problems caused by stress non-uniformity, an optimal weight was found where after sufficient compression the distance between the apex of the convex side of the tablet and the bottom of the V-shaped opening on top will be minimal while still allowing for adequate manufacturability.

Having established the critical tablet weight, it was expected that compositions containing the active ingredient would tablet in an acceptable manner because acceptable tablets could be made at this composition using conventional tools. However, unexpectedly, it was found that a critical binder-lubricant relationship was needed to produce acceptable tablets with deep scoring tooling.

Four experiments were designed to select the most optimal tablet weight for the easy-break design. The data is shown in Example I.

EXAMPLE I TOTAL TABLET WEIGHT OPTIMIZATION

All experiments were run in duplicates from one stock powder mixture and directly compressed on a rotary tablet press. The material run was an optimal placebo mixture as described below:

    __________________________________________________________________________     FORMULAE      A     B     C     D                                              __________________________________________________________________________     Lactose hydrous U.S.P.                                                                       qs    qs    qs    qs                                             Microcrystalline Cellulose                                                                   25 w/o                                                                               25 w/o                                                                               25 w/o                                                                               25 w/o                                         Magnesium Stearate U.S.P.                                                                    0.25 w/o                                                                             0.25 w/o                                                                             0.25 w/o                                                                             0.25 w/o                                       Total Tablet Weight                                                                          230 mg                                                                               200 mg                                                                               175 mg                                                                               150 mg                                         __________________________________________________________________________

The pharmaceutical term "qs" is an abbreviation of the Latin phrase "quantum sufficiat" which means as much as suffices. The abbreviation "w/o" means percent by weight.

The results were as follows:

Formula a: exhibits capping, high friability, in the ranges of 7-15 Strong Cobb units (s.c.u.) hardness; the friability was 2% - 5% by Roche friabilator.

Formula b: repeated the behavior of Formula A on a somewhat reduced scale.

Formula c: produced satisfactory tablet hardness of 8-14 s.c.u. and friability of 0.0% at that range.

Formula d: produced satisfactory tablets.

Initially it was tried to utilize a conventional isosorbide dinitrate formula and weight for the easy-break tableting tools. It was expected that the design would perform adequately at a total weight of 230 milligrams (mg). Surprisingly the tablets made at this weight were unsatisfactory, and evidenced capping, high friability in addition to insufficient tablet hardness. An attempt was made to solve the problem by selecting the most adequate tablet weight to achieve better manufacturability, but was unsuccessful.

The weight selection experiments indicated that in order to achieve adequate tableting parameters with deep scoring tooling the tablet weight will have to be under 200 mg. The optimum weight is about 175 mg because at 150 mg there is a high probability of tooling contact which in turn may cause damage to the punch tips.

Once the weight problem was solved, no further problems were anticipated. However, upon careful scrutiny of the tableting performance there was found an unexpected problem in the binder and lubricant relationship. "Picking" and "sticking" were found in some cases, and soft tablets with capping in others. In order to resolve the problem a set of experiments was designed to determine the critical nature of the binder and lubricant levels. The experiments are shown in Example II:

EXAMPLE II

Following the procedure of Example I a series of formulations were prepared and deeply scored tablets were made from them. The formulations are shown in Table I.

                                      TABLE I                                      __________________________________________________________________________                     PERCENT OF TOTAL TABLET WEIGHT                                 FORMULAE        A      B   C   D   E   F   G   H   I   J   K                   __________________________________________________________________________     Microcrystalline Cellulose                                                                     25     25  25  25      45  45  25  25  25  60                  *Solka-floc                                    10                              Lactose hydrous qs         qs  qs  qs  qs  qs  qs  qs  qs  qs                  Lactose anhydrous      63                                                      Dicalcium Phosphate                                                            **Sta-Rx 1500                      74                                          Magnesium Stearate                                                                             0.22   0.3 0.22                                                                               0.22                                                                               0.3 0.22                                                                               0.35                                                                               0.3 0.3 0.4 0.35                Stearic Acid                                                                   ***Stero-Tex               0.50                                                Talc                           2                                               Isosorbide Dinitrate                                                           Trituration     20.0   20.0                                                                               20.0                                                                               20.0                                                                               20.0                                                                               20.0                                                                               20.0                                                                               20.0                                                                               20.0                                                                               20.0                                                                               20.0                                mg     mg  mg  mg  mg  mg  mg  mg  mg  mg  mg                  Total Weight    175 mg 175 mg                                                                             175 mg                                                                             175 mg                                                                             175 mg                                                                             175 mg                                                                             175 mg                                                                             175 mg                                                                             175 mg                                                                             175                                                                                175 mg              __________________________________________________________________________                                                                1                    Formulas A through H with the exception of G did not exhibit adequate          manufacturability in a direct compression process.                             *Purified Cellulose, Brown Co.                                                 **Directly compressible starch                                                 ***Edible vegetable oil, powdered lubricant                              

Shown in Table I are drug amounts of 20 mg/tablet each. These correspond to a tablet containing 5 mg. of isosorbide dinitrate which is utilized in a 25 weight percent mixture with lactose being 75 weight percent. To prepare a 10 mg. isosorbide dinitrate tablet 40 mg. of drug-lactose mixture would be used (representing 10 mg. of isosorbide dinitrate). The change in dosage is balanced with the amount of lactose in the formulation while producing similar results.

The results were as follows:

Formula a exhibited severe picking on the upper face of the tablet.

Formula b contained the minimal level of anhydrous lactose to produce an adequate tablet. However, the tablet demonstrated poor disintegration.

Formula c produced soft tablets that capped while still picking.

Formula d exhibited insufficient hardness range and picking on both tablet faces.

Formula e showed insufficient binding resulting in very soft tablets having high friability.

Formula f showed inadequate performance because of slight pick.

Formula g showed adequate manufacturability as to hardness and friability. The tablets were free of picking.

Formula h showed insufficient hardness with picking on bottom face.

Formula i was a slugged formula which exhibited binding and picking on the tablet lower face.

Formula j was a slugged formula with a higher lubricant level which produced adequate lubrication but insufficient hardness.

Formula k showed excellent manufacturability for all parameters.

Based on the foregoing it was determined that tablets made of conventional pharamceutical ingredients would manufacture adequately at weights under 200 mg. utilizing a deeply scored design. In addition, a great amount of experimentation and design was spent on the tablet formulation to overcome the critical nature of its binder and lubricant dependence.

From the foregoing the preferred weight for deeply grooved tablets is 150 to 175 mg. The preferred ratio of lubricant to binder is obtained when the binder constitutes 45 to 99.7 w/o and the lubricant constitutes 0.3 to 0.4 w/o of tablet exclusive of the amount of the active ingredient, fillers, extenders, flavor and the like. That is, the weight percent of the binder and lubricant is based on the portion of the tablet composition usually referred to as "q.s.".

Only microcrystalline cellulose of the binders presently available on the market has been found to be useful in deep grooved tablet compositions. Only the stearates, including stearic acid, of the lubricants presently available on the market have been found to be useful in deep grooved tablet compositions.

A particularly advantageous formula weighs 175 mg. per tablet and contains 60 percent by weight microcrystalline cellulose with 0.35 percent by weight of magnesium stearate.

For assuring of distintegration and dissolution reproducibility the use of one (1) percent Amberlite is optional and has been tested to that effect.

The Mannitol U.S.P. used in the examples is the conventional powdered form rather than the granular form.

Formulae A, B, D, E and F are directly compressed.

Formula A exhibited very high friability, capping and a narrow hardness range.

In Formula B the weight has been reduced, but tablets still exhibit heavy capping and friability with very low hardness.

Formula C was a wet granulated formula, and exhibited high friability, capping and inadequate chewability due to the wet binder.

Formula D shows adequate manufacturability and chewability.

In Formula E reduced lubricant level results in heavy picking on both tablet faces.

In Formula F eliminating the sweetener from Formula D maintains adequate manufacturability with improved taste.

Formula G was slugged and exhibited capping, narrow hardness range and slight picking.

Formula H produced adequate tableting characteristics

From the foregoing it was concluded that 10 mg. chewable tablets were successfully made in two formulations: 1. The first formulation uses a directly compressed mannitol and a dextrose and corn syrup solids granulation in combination; 2. The second formulation uses dextrose and corn syrup solids granulation without mannitol in direct compression.

The choice between these two categories depends strictly on personal taste preference. Both formulae will produce similarly adequate results.

EXAMPLE III Preparation of 10 Mg. Isosorbide Dinitrate Chewable Tablets

The deeply scored design was also utilized in the manufacture of a chewable tablet form containing isosorbide dinitrate at a 10 mg. level.

Again, in this formula is was found necessary to resort to a lower tablet weight of 175 mg. In addition because the design of a chewable tablet requires the incorporation of a chewable carrier, it was necessary to evaluate different chewable materials to obtain a sufficiently cohesive and well lubricated direct compression formula. The data obtained in those experiments is shown in Table II in which the tablets were prepared as described in Example I.

The preferred embodiment at which chewable deeply scored tablets can be made is for the first category with

                                      TABLE II                                     __________________________________________________________________________                   CHEWABLE TABLETS                                                 FORMULAE      A    B    C    D    E    F    G      H                           __________________________________________________________________________     Isosorbide Dinitrate (25%)                                                                   40 mg                                                                               40 mg                                                                               40 mg                                                                               40.0 mg                                                                             40 mg                                                                               40 mg                                                                               40.0 mg                                                                               40.0 mg                     Lactose mixture                                                                *Nutab        qs   qs                                                          Mannitol U.S.P.         qs   20%  20%  20%  qs                                 **Cellutab, anhydrous        31.5%                                                                               31.5%                                                                               31.5%       qs                          Microcrystalline Cellulose                                                                   25.0%                                                                               20%       25%  25%  25%  25%    20%                         Solka floc         8.0%                                                        Magnesium Stearate U.S.P.                                                                    0.6% 0.7% 1.0% 1.0% 0.5% 0.9% 0.9%+0.9%                                                                             0.35%                       FD&C Yellow No. 5 Lake                                                                       0.1% 0.1% 0.4% 0.4% 0.4% 0.4% 0.4%   0.4%                        Sodium Saccharine N.F.  0.08%                                                                               0.08%                                                                               0.08%                                                                               --   0.08%  --                          Methyl Cellulose 400 cps                                                                               0.7%                                                   Lemon Oil, spray dried  1.7% 1.7% 1.7% 1.7% 1.7%   1.7%                        Total Tablet Weight                                                                          222.5                                                                               196  190  175.0                                                                               175  175  175.0  175                                       mg   mg   mg   mg   mg   mg   mg     mg                          __________________________________________________________________________      *Sucrose, invert sugar, starch, magnesium stearate direct compression          granulation.                                                                   **Dextrose and corn syrup solids granulation.                            

at least 20 percent by weight of microcrystalline cellulose, 31.5 percent by weight of Cellutab anhydrous, 25 percent Mannitol and a range of 0.7-1.0 percent by weight of magnesium stearate or: at the second category with Cellutab anhydrous and a minimum of 0.35 percent by weight of magnesium stearate.

The incorporation of an ingredient which would serve as a chewable carrier, one which imparts a certain pallatable feeling, sweetness and desirable chewability, presents additional variables to the ones already described above. When processing and formulating for such purpose, it is necessary to consider the properties producing the resulting chewable quality of the tablet, that is hardness, taste and pallatability. The majority of chewable carriers, apart from the granulated natural sugars and their derivatives, do not lend themselves to direct compression and tend to lose some of their taste upon any granulation-method.

The examples illustrated in Table II present the compositions pharmaceutical tablets manufactured by three basic methods: direct compression, dry granulation, and wet granulation. These examples are not to be construed as limiting the scope of this invention which may only be determined by reference to the appended claims. 

What is claimed is:
 1. A chewable pharmaceutical tablet which is adequately imprinted with indicia or embossing and scored to form a groove which is 1/3 to 2/3 the depth of the total tablet thickness to facilitate separation into subdivisions containing substantially equal amounts of pharmaceutically active ingredient comprising a directly compressed formulation of:

    ______________________________________                                         A.    Active ingredient  5 to 10 milligrams                                    B.    Microcrystalline Cellulose                                                                        20 to 25 percent                                                               by weight                                             C.    Dextrose and corn syrup                                                                           30 to 55 percent                                            solids granulation by weight                                             D.    Mannitol           20 to 30 percent                                                               by weight                                             E.    Magnesium stearate 0.9 to 1.0 percent -  by weight -F. The                                        remainder being                                             pharmaceutically acceptable                                                    fillers, extenders, flavoring                                                  and the like.                                                            ______________________________________                                    


2. A tablet as defined in claim 1 in which the ingredients are present in the following amounts:

    ______________________________________                                         A.    Microcrystalline cellulose                                                                        20 percent by                                                                  weight                                                B.    Dextrose and corn syrup                                                                           31.5 percent by                                             solids granulation weight                                                C.    Mannitol           25 percent by                                                                  weight                                                D.    Magnesium stearate 1 percent by weight                                   ______________________________________                                    


3. A tablet as defined in claim 1 in which the total tablet weight is 150 to 175 milligrams.
 4. A tablet as defined in claim 1 in which the total tablet weight is about 175 milligrams.
 5. A tablet as defined in claim 1 in which the active ingredient is 10 milligrams of isosorbide dinitrate.
 6. A chewable pharmaceutical tablet which is deeply adequately imprinted with indicia or embossing and scored to form a groove which is 1/3 to 2/3 the depth of the total tablet thickness to facilitate separation into subdivisions containing substantially equal amount of a pharmaceutically active ingredient comprising a directly compressed formulation of:

    ______________________________________                                         A.   Active ingredient   5 to 10 milligrams                                    B.   Microcrystalline Cellulose                                                                         20 to 25 percent                                                               by weight                                             C.   Dextrose and corn syrup solids                                                                     50 to 55 percent                                           granulation         by weight                                             D.   Magnesium stearate  0.35 to 0.4 per-                                                               cent by weight                                        E.   Pharmaceutically acceptable                                                                        remainder                                                  fillers, extenders, flavoring                                                  and the like.                                                             ______________________________________                                    


7. A tablet as defined in claim 6 in which the total tablet weight is 150 to 175 milligrams.
 8. A tablet as defined in claim 6 in which the total tablet weight is 175 milligrams.
 9. A tablet as defined in claim 6 in which the active ingredient is 10 milligrams of isosorbide dinitrate. .Iadd.
 10. A chewable pharmaceutical tablet which is adequately imprinted with indicia or embossing and scored to form a groove which is 1/3 to 2/3 the depth of the total tablet thickness to facilitate separation into subdivisions containing substantially equal amounts of pharmaceutically active ingredient comprising a directly compressed formulation of an effective amount of an active ingredient and:

    ______________________________________                                         .Iadd.A..Iaddend.                                                                  .Iadd.Microcrystalline Cellulose.Iaddend.                                                         .Iadd.20 to 25 percent by weight.Iaddend.               .Iadd.B..Iaddend.                                                                  .Iadd.Dextrose and corn syrup.Iaddend.                                                            .Iadd.30 to 55 percent by weight.Iaddend.                   .Iadd.solids granulation.Iaddend.                                          .Iadd.C..Iaddend.                                                                  .Iadd.Mannitol.Iaddend.                                                                           .Iadd.20 to 30 percent by weight.Iaddend.               .Iadd.D..Iaddend.                                                                  .Iadd.Magnesium stearate.Iaddend.                                                                 .Iadd.0.9 to 1.0 percent by.Iaddend.                                           .Iadd.weight.Iaddend.                                   .Iadd.E..Iaddend.                                                                  .Iadd.The remainder being.Iaddend.                                             .Iadd.pharmaceutically acceptable.Iaddend.                                     .Iadd.fillers, extenders, flavoring.Iaddend.                                   .Iadd.and the like..Iaddend.                                               ______________________________________                                          .Iadd.
 11. A chewable pharmaceutical tablet which is deeply adequately      imprinted with indicia or embossing and scored to form a groove which is      1/3 to 2/3 the depth of the total tablet thickness to facilitate      separation into subdivisions containing substantially equal amounts of a      pharmaceutically active ingredient comprising a directly compressed      formulation of an effective amount of an active ingredient and:

    ______________________________________                                         .Iadd.A..Iaddend.                                                                  .Iadd.Microcrystalline Cellulose.Iaddend.                                                        .Iadd.20 to 25 percent by weight.Iaddend.                .Iadd.B..Iaddend.                                                                  .Iadd.Dextrose and corn syrup.Iaddend.                                                           .Iadd.50 to 55 percent by weight.Iaddend.                    .Iadd.solids granulation.Iaddend.                                          .Iadd.C..Iaddend.                                                                  .Iadd.Magnesium stearate.Iaddend.                                                                .Iadd.0.35 to 0.4 percent by weight.Iaddend.             .Iadd.D..Iaddend.                                                                  .Iadd.Pharmaceutically.Iaddend.                                                                  .Iadd.remainder.Iaddend.                                     .Iadd.acceptable fillers,.Iaddend.                                             .Iadd.extenders, flavoring.Iaddend.                                            .Iadd.and the like..Iaddend.                                               ______________________________________                                     